Perforin gene mutations in 77 Chinese patients with lymphomas.docVIP

Perforin gene mutations in 77 Chinese patients with lymphomas 　　BACKGROUND： Perforin gene （PRF1） mutations have been reported in patients with lymphoma， but the prevalence and characteristics of PRF1 mutation have not been identified in Chinese patients with lymphoma. 　　METHODS： Seventy-seven patients with lymphoma， including 6 patients with Hodgkin lymphoma and 71 patients with non-Hodgkin lymphoma， were recruited. DNA samples from peripheral blood were used for PRF1 mutation detection by the PCR-sequencing method. 　　RESULTS： Eleven novel PRF1 mutations were found in 8 of the 77 patients wi