ModelforTMZinhibitingcardiacfibrosis.pptVIP

Model for TMZ inhibiting cardiac fibrosis. Xuehui Liu et al. Cardiovasc Res 2010;88:150-158 Published on behalf of the European Society of Cardiology. All rights reserved. ? The Author 2010. For permissions please email: journals.permissions@oxfordjournals.org. Model for TMZ inhibiting cardiac fibrosis. TMZ suppresses Ang II-induced NADPH oxidase activation which is the main source of ROS generation, decreases its downstream-CTGF synthesis, and attenuates cardiac fibroblast proliferation and collagen synthesis.