BrainMRIoftumor-bearingmicetreatedwith50mgkgZD.pptVIP

Brain MRI of tumor-bearing mice treated with 50 mg/kg ZD6474 from day 1, 5, 9, or 17 after inoculation of tumor cells, as indicated. William P. J. Leenders et al. Clin Cancer Res 2004;10:6222-6230 ?2004 by American Association for Cancer Research Brain MRI of tumor-bearing mice treated with 50 mg/kg ZD6474 from day 1, 5, 9, or 17 after inoculation of tumor cells, as indicated. T1-weighted Gd-DTPA-enhanced images were acquired at day 20, before A?D, top panels and directly after A?D, bottom panels intravenous injection of the contrast agent. Clearly, at this dose of ZD6474, VEGF-induced ve