Composite tissue adhesive.docVIP

Composite tissue adhesive Abstract Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of chemically derivatized soluble collagen which is formulated to concentrations ranging from 300 mg/ml (30%) to 800 mg/ml (80%) collagen protein. In particular, Type I collagen, for example, is first prepared by extraction from bovine or porcine hide and purified. The collagen preparations are then chemically derivatized with sulfhydryl reagents to improve cohesive strength and with secondary derivatizing agents, such as carboxyl groups, to improve the adhesive strength of the solder to the tissue. The compositions are then formed into viscous solutions, gels or solid films, which when exposed to energy generated from an infrared laser, for example, undergo thermally induced phase transitions. Solid or semi-solid protein compositions become less viscous enabling the high concentration protein to penetrate the interstices of treated biological tissue or to fill voids in tissue. As thermal energy is released into the surrounding environment, the protein compositions again become solid or semi-solid, adhering to the treated tissue or tissue space. Inventors: Soltz; Barbara A. (Spring Valley, NY), DeVore; Dale P. (Chelmsford, MA), DeVore; Braden P. (Westerly, RI), Soltz; Robert (Spring Valley, NY), Soltz; Michael A. (Pleasanton, CA) Assignee: Tissue Adhesive Technologies, Inc. (Spring Valley, NY) Appl. No.: 09/973,335 Filed: October 9, 2001 Current U.S. Class: 606/214 ; 424/422; 606/213; 606/215 Current International Class: A61B 17/03 ; A61B 017/03 () Field of Search: 606/213,214,215  References Cited [Referenced By] U.S. Patent Documents 4713446 December 1987 DeVore et al. 4969912 November 1990 Kelman et al. 5104957 April 1992 Kelman et al. 5156613 October 1992 Sawyer 5164139 November 1992 Fujioka et al. 5