electron transport and oxidative phosphorylation outline.pptVIP

electron transport and oxidative phosphorylation outline Group 10 Electron transport chain An electron transport chain ETC couples electron transfer between an electron donor such as NADH and an electron acceptor such as O2 with the transfer of H+ ions protons across a membrane . Mitochondrial redox carriers Four membrane-bound complexes have been identified in electron transportion：Complex I, Complex II, Complex III, and Complex IV. Complex I Complex II Complex IV Oxidative Phosphorylation Oxidative phosphorylation or OXPHOS in short is a metabolic pathway that uses energy released by the oxidation of nutrients to produce adenosine triphosphate ATP . ATP synthase How many ATPs are generated by a molecular of glucose? Glycolysis 2 ATP Citric Acid Cycle 2 GTP Oxidative Phosphorylation 26 28 ATP NADH + H+ FMN FMNH2 NAD+ 2Fe--S CoQ CoQH2 FMN 2H+ + 2H+ Complex I oxidizes NADH and reduces Coenzyme Q, it results in the net transport of 4 protons from the metrix side to the intermembrane space every 2 electrons passed. H+/2e- Amytal a barbiturate drug 　rotenone a plant product commonly used as an insecticide 　piericidin A an antibiotic 　inhibit electron flow from　the Fe-S centers of Complex I to ubiquinone Complex II oxidizes succinate and reduces coenzyme Q, but the small energy change of this energy 0.029v is not sufficient to drive the transport of protons across the inner mitochondrial membrane. Complex III Q cycle QH2 + 2 cytc1 oxidized + 2HN+ → Q + 2 cytc1 reduced + 4HP+ 4 Fe2+-cytc + 8 H+ + O2 → 4 Fe3+-cytc + 2 H2O + 4 H+ A model for the electron transport in the mitochondrial inner membrane. Flow of protons through a subunit turns the rotor and drivers the cycle of confromational change in αandβthat synthesize ATP.