2013生物药物概况.pptVIP

* Lecture Notes Several molecules have been developed that are variants of naturally occurring t-PA. TNK has nearly the same general amino acid sequence as naturally occurring t-PA, but has been altered in 3 locations. The molecule consists of several morphologically distinct regions with identifiable functions. The fibronectin (fingerlike) domain—responsible for high-affinity fibrin binding. The kringle 1 and epidermal growth factors—account for receptor binding in the liver and rapid clearance from the plasma. The kringle 2 domain—associated with lysine binding and accelerates conversion of