drug_metabolism_2006-2007.ppt

Drug Metabolism S.P. Markey Laboratory of Neurotoxicology NIMH, NIH Evolution of Drug Metabolism As a SciencePost WWII Pioneers Richard Tecwyn Williams – Great Britain 1942, worked on the metabolism on TNT with regard to toxicity in munitions workers; due to the war he assembled teams to work on metabolism of sulfonamides, benzene, aniline, acetanilide, phenacetin, and stilbesterol Developed concept of Phase 1 Phase 2 Reactions. Biotransformation involves metabolic oxygenation, reduction, or hydrolysis; result in changes in biological activity (increased or decreased) Second phase, c