Adrenergic agents copy.pptVIP

Noradrenergic neurons and adrenergic receptors are important targets of many pharmacological agents. As such, they contribute to the mechanisms of action of a number of classes of therapeutic agents and/or in their side effects. The major endogenous agonists for adrenergic receptors are norepinephrine, epinephrine, and dopamine. These are all catecholamines. Metabolism of nor-Epinephrine Transmembrane topology of adrenoceptors Primary structure of b-adrenoceptors:functional domains Classification of adrenoceptors 1896 Oliver and Schafer-adrenal extracts increase BP 1913 Dale- adrenalin