信号通路与肿瘤发生II0526讲义.ppt

细胞信号传导与肿瘤发生 TNF NF- κB信号 1975年，E. A. Carswell和L. J. Old等人发现已接种卡介苗的小鼠注射脂多糖后，小鼠血清中产生了一种可引起动物肿瘤组织出血坏死的物质，该物质对体外培养的多种肿瘤细胞株都具有细胞杀伤作用，于是他们将这种物质命名为肿瘤坏死因子（tumour necrosis factor, TNF）。TNF是迄今发现的抗肿瘤效果最强的细胞因子。 TNF的发现 1968, Dr. Gale A Granger from the University of California, Irvine, reported a cytotoxic factor produced by lymphocytes and named it lymphotoxin (LT).[ 1968，Dr. Nancy H. Ruddle from Yale University, who reported the same activity in a series of back-to-back articles published in the same month and year. 1975 Dr. Lloyd J. Old from Memorial Sloan-Kettering Cancer Center, New York, reported a