第四版第16章__细胞死亡与细胞衰老重点分析.ppt

以线虫为研究材料。线虫属于线形动物，是我们熟知的蛔虫的近亲。线虫长仅１毫米，通体透明，便于用显微镜观测。它的体细胞数目是恒定的，共1090个，其中131个在发育过程中发生细胞“程序性死亡”。 * * The binding of B cell lymphoma 2 (BCL-2) homology 3 domain (BH3)-only proteins to BCL-2-associated X protein (BAX) and BCL-2 antagonist or killer (BAK) leads to extensive conformational changes during their activation. The BH3 domain and hydrophobic cleft are exposed, allowing symmetrical BAX or BAK dimers to form through reciprocal BH3 domain–cleft interactions. During activation, a dimer–dimer interaction surface is also exposed, allowing higher-order oligomers to form. Higher-order oligomers