学位论文---丙型肝炎治疗药物研究与设计.docVIP

目录 丙型肝炎治疗药物研究与设计………………………………………………………3 以生命周期划分HCV治疗药物整理………………………………………4 HCV的结构………………...……………………………………………4 HCV生命周期………………………………………………………...…5 以生命周期划分HCV治疗药物整理…………………………..............6 总结和展望………………………...…………………………..……….13 基于NS5A抑制剂的创新药物设计………………………………………14 前言..........................................................................................................14 NS5A靶点...............................................................................................14 NS5A抑制剂研究进展...........................................................................15 BMS-790052(daclatasvir)研究................................................................20 创新药物设计..........................................................................................24 参考文献..................................................................................................26 TLR-7激动剂研究与设计………………………………………………….29 目前已开发的激动剂..............................................................................29 咪唑喹啉胺（imidazoquinoline amine）类..................................29 1-取代吡唑啉酮Substituted Pyrazolo(3,4-C) Ring）类......31 8-氧-去氮嘌呤类/咪唑并吡啶酮类............................................32 8-羟基腺嘌呤（8-Hydroxyadenine）类......................................36 扩环8-羟基腺嘌呤类..................................................................57 艾沙托立宾（Isatoribine）衍生物类..........................................61 Bitriazolyl Acyclonucleoside类...................................................64 三氮唑类（Triazole）.................................................................65 嘧啶类（Pyrimidine）.................................................................66 8-Substitued Benzoazepines类....................................................68 Aminodiazepine类.......................................................................69 未来可能的变动空间..............................................................................70 创新药物设计..........................................................................................71 参考文献.............