Widespreadseasonalgeneexpressionrevealsannual.docxVIP

Widespread seasonal gene expression reveals annual differences in human immunity and physiology普遍存在的季节性基因表达揭示了人类免疫和生理的年度性差异Xaquin Castro Dopico1,*, Marina Evangelou1,*, Ricardo C. Ferreira1, Hui Guo1, Marcin L. Pekalski1,Deborah J. Smyth1, Nicholas Cooper1, Oliver S. Burren1, Anthony J. Fulford2, Branwen J. Hennig2,Andrew M. Prentice2, Anette-G. Ziegler3, Ezio Bonifacio4, Chris Wallace1,5,** John A. Todd1,**Seasonal variations are rarely considered a contributing component to human tissue function or health, although many diseases and physiological process display annual periodicities.Here we