AI-2群体感应系统抑制剂细菌生物膜感染的潜在新药-第三军医大学学报.docVIP

AI-2群体感应系统抑制剂生物膜群体感应系统luxS/AI-2；细菌耐药；毒力因子 AI-2 quorum sensing inhibitors: potential drug to bacterial biofilm infections Xia Peiyuan, Shi Huiqing (Department of Pharmacy, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China) [Abstract] Bacterial biofilms possess strong drug resistance and can evade from immune attack, resulting in chronic infection, which is difficult to control and can’t be effectively treated by conventional anti-infective therapy. In the searching of an effective drug therapeutic target for anti-biofilm, bacterial quorum sensing (QS) system has b