06-Microarray_data_analysis(生物信息学国外教程2010版).ppt

Data matrix (20 genes and 3 time points from Chu et al., 1998) Software: S-PLUS package Fig. 7.8 Page 205 genes samples (time points) 3D plot (using S-PLUS software) t=0 t=0.5 t=2.0 Fig. 7.8 Page 205 Descriptive statistics: clustering Clustering algorithms offer useful visual descriptions of microarray data. Genes may be clustered, or samples, or both. We will next describe hierarchical clustering. This may be agglomerative (building up the branches of a tree, beginning with the two most closely related objects) or divisive (building the tree by finding the most dissimilar objects first).