支气管扩张剂作用的分子药理机制_培训课件.pptVIP

* Salbutamol is a short-acting ?2-agonist with a short side chain. Therefore, salbutamol is hydrophilic, i.e. it diffuses predominantly into the aqueous phase around cell membranes of the lung Formoterol has a medium-size side chain. Therefore, it is less hydrophilic and more lipophilic than salbutamol, i.e. it diffuses both into the aqueous phase and cell membranes of the lung Salmeterol is a long-acting ?2-agonist with a long side chain. Therefore, salmeterol is lipophilic, i.e. it diffuses quickly from the aqueous phase into cell membranes of the lung * The plasmalemma microkinetic dif