文献汇报课程.pptVIP

EXPERIMENTAL PROCEDURES CD Measurements Amino Acid Sequence Data of Anti-NP mAbs Numbering of the Amino Acid Residues in CDR-H3 Assignment of CDR-H3 Conformations Molecular Modeling of the Ag-combining Site DISCUSSION A mutation from TrpH33 to LeuH33 (a feature of Abs of group L) brought about a 10-fold increase in rules. The mAbs of class A had a tendency to form CDR-H3 with a rigid β-hairpin structure on a kinked base. A flexible structure could afford versatility in constructing the Ag-combining site into diverse forms, although a number of adjustments at various sites would be required. W