FDA批准的抗肿瘤药物19492003.doc

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FDA批准的抗肿瘤药物19492003

Drug Name Trade Name Indictions Manufacturer Time chlorambucil Leukeran Chronic Lymphocytic Leukemia- palliative therapy GlaxoSmithKline ? meclorethamine, nitrogen mustard Mustargen ? Merck Mar 15 1949 leucovorin Wellcovorin, Leucovorin Leucovorin calcium is indicated fro use in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer. Immunex Corporation Jun 20 1952 mercaptopurine, 6-MP Purinethol ? GlaxoSmithKline Sep 11 1953 methotrexate Methotrexate ? Lederle Laboratories Dec 07 1953 busulfan oral Myleran Chronic Myelogenous Leukemia- palliative therapy GlaxoSmithKline Jun 26 1954 chlorambucil Leukeran ? GlaxoSmithKline Mar 18 1957 thiotepa Thioplex ? Immunex Corporation Mar 09 1959 methotrexate Methotrexate ? Lederle Laboratories Aug 10 1959 nandrolone phenpropionate Durabolin-50 ? Organon Oct 30 1959 cyclophosphamide Cytoxan, Neosar ? Bristol-Myers Squibb Nov 16 1959 cyclophosphamide Cytoxan Injection ? Bristol-Myers Squibb Nov 16 1959 DROMOSTANOLONE PROPIONATE DROMOSTANOLONE ? Eli Lilly Oct 26 1961 fluorouracil, 5-FU Adrucil prolong survival in combination with leucovorin ICN Puerto Rico Apr 25 1962 Uracil Mustard Uracil Mustard Capsules ? Roberts Labs Sep 13 1962 vincristine Oncovin ? Eli Lilly Jul 10 1963 vincristine Oncovin ? Eli Lilly Jul 10 1963 vincristine Oncovin ? Eli Lilly Jul 10 1963 vincristine Oncovin ? Eli Lilly Jul 10 1963 vincristine Oncovin ? Eli Lilly Jul 10 1963 vincristine Oncovin ? Eli Lilly Jul 10 1963 vincristine Oncovin ? Eli Lilly Jul 10 1963 melphalan, L-PAM Alkeran ? GlaxoSmithKline Jan 17 1964 dactinomycin, actinomycin D Cosmegen ? Merck Feb 04 1964 DROMOSTANOLONE PROPIONATE MASTERONE INJECTION ? SYNTEX Oct 08 1964 quinacrine

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