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Laryngopharyngeal Reflux and Voice Disorders: An Overview on Disease Mechanisms, Treatments, and Research Advances
Author:?Robert T. Sataloff
Specialty:?Otolaryngology,?Surgery,?Voice SpecialistInstitution: Department of Otolaryngology – Head and Neck Surgery, Drexel University College of MedicineAddress: Philadelphia, Pennsylvania, United States
Author:?Mary J. Hawkshaw
Specialty:?OtolaryngologyInstitution: Department of Otolaryngology – Head and Neck Surgery, Drexel University College of MedicineAddress: Philadelphia, Pennsylvania, United States
Author:?Reena Gupta
Specialty:?OtolaryngologyInstitution: Department of Otolaryngology – Head and Neck Surgery , Drexel University College of MedicineAddress: Philadelphia, Pennsylvania, 19103, United States
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Abstract:?Laryngopharyngeal reflux (LPR) is common. Nevertheless, controversy persists regarding its pathophysiology, diagnosis, and treatment. Research studies have been unconvincing, and contradictory in some cases. Standards of diagnosis remain controversial, and there is a paucity of incontrovertible data confirming efficacy of treatment. Because of the high prevalence of LPR and its potential serious consequences (including laryngeal carcinoma), it is important for physicians to be familiar with contemporary perspectives on this disorder, current standards of patient care, and the need for additional multidisciplinary research.
Introduction
Laryngopharyngeal reflux?(LPR) is an extraesophageal variant of?gastroesophageal reflux disease(GERD) that affects the larynx and pharynx. In recent years, many otolaryngologists have acknowledged the existence and potential importance of LPR in patients with otolaryngologic complaints (Sataloff et al., 2006a), although the association between acid reflux and laryngeal abnormalities has been recognized for more than four decades (von Leden and Moore, 1960; Pesce and Caligar
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