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Targeting Liver Fibrosis: Strategies for Development and Validation of Antifibrotic Therapies 针对肝纤维化：抗纤维化治疗的发展和检验的策略 We have made striking progress in our understanding of the biochemistry and cell biology that underlies liver fibrosis and cirrhosis, including the development of strategies and agents to prevent and reverse fibrosis. 我们已经在现今的生物化学和细胞生物学上构成肝脏纤维变性和肝硬变的However, translation of this knowledge into clinical practice has been hampered by 但是，把这种理论应用到临床实践上受到了阻碍： the limitation of many in vitro and in vivo models to confirm mechanisms and to test antifibrotic agents, （1）许多体外和体内模型机制and