某农村人群甲、乙、丙、戊和庚型肝炎病毒感染的现况研究行政.docVIP

某农村人群甲、乙、丙、戊和庚型肝炎病毒感染的现况研究行政论文... 某农村人群甲、乙、丙、戊和庚型肝炎病毒感染的现况研究 　　【摘要】　目的　了解某农村人群甲、乙、丙、戊和庚型肝炎病毒的感染状况及其流行特点。方法　应用酶联免疫试验(eia)检测血清抗-hav、hbsag、抗-hbs、抗-hbc、抗-hcv、抗-hev和抗-hgv，并对抗-hgv阳性者应用套式逆转录聚合酶链反应法(rt-npcr)检测hgv rna。结果　该人群抗-hav、抗-hcv、抗-hev和抗-hgv流行率分别为86.9%、11.5%、2.9%和1.8%，hbsag阳性率为8.0%，hbv总感染率为54.8%。hav以5岁以下儿童感染率最低(35.0%)，到10岁时85.0%的儿童已感染hav。hbsag阳性率呈现两个高峰，分别在5～9岁和40～49岁年龄组；hbv总感染率到10岁时为55.0%，然后随年龄增长而上升。hcv感染主要集中在20～49岁年龄组(占77.8%)。各型肝炎病毒男女感染率无明显差异。献浆次数、年限与hcv、hev、hgv感染呈正相关。hbsag、抗-hbc、抗-hcv呈现家庭聚集性，但仅hbsag呈现母亲与子女相关。抗-hcv阳性者中alt异常率(15.9%)显著高于抗-hcv阴性者(1.2%，p＜0.01)。结论　该人群甲、乙、丙、戊和庚型肝炎病毒感染具有不同的流行病学特点；献血浆是该人群hcv、hev和hgv感染的主要危险因素；抗-hcv阳性者多伴有肝损害。 a cross-sectional study on hav,hbv,hcv,hev and hgv infection in a rural population 　　【abstract】　objective　to study the epidemiological characteristics of hav,hbv,hcv,hev and hgv infections in a rural population. methods　enzyme immunoassays were used for detection of anti-hav,hbsag,anti-hbs,anti-hcv,anti-hev and anti-hgv. anti-hgv positive sera were further tested for hgv rna using a reverse transcription nested pcr. results　the prevalence rates of anti-hav,hbsag,anti-hcv,anti-hev,anti-hgv in the studied population were 86.9%,8.0%,11.5%,2.9% and 1.8%,respectively. the total infection rate of hbv was 54.8%. the hav infection rate of children below 5 was the lowest (35.0%) as compared with other age groups.amp;n bsp;85.0% of children at 10 years old had already been infected with hav. the hbsag positive rate showed two peaks at 5-9 and 40-49 age groups. the total infection rate of hbv was 55.0% in the age group less than 10 years old and increased with age. hcv infection mainly occurred in the age group of 20-49 (77.8%). the prevalence rates of anti-hcv,anti-hev and anti-hgv increased with the frequencies and duration of plasma donation. family clusterings of hbsag,anti-hbc and anti-hcv were observed. however,only with hbsag showed a correlation between mothers and their offspring.the frequency of abnormal　alt in anti-hcv　positiv