临床药师参与真菌药物治疗总结与研究_培训课件.pptVIP

如何确定疗程？ 对深部真菌病的治疗而言，实在无法事先确定一个适宜的剂量和疗程，停药的指征主要依据临床改善的程度和真菌学监测的结果。 * A different drug target: The most overt distinction between fungal and mammalian cells is the cell wall of fungi. The uniqueness of this structure makes it a premier target of antifungal drugs. Although the cell wall was initially considered an almost inert cellular structure that protected the cell against osmotic offense, more recent studies have demonstrated that it is a dynamic organelle. The major components of the cell wall are glucan and chitin, which are associated with structural rigidity, and mannoproteins. * 是临床