网站大量收购闲置独家精品文档,联系QQ:2885784924

浆细胞病_培训课件.ppt

  1. 1、本文档共98页,可阅读全部内容。
  2. 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
  3. 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  4. 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
* Slide 133. Bortezomib vs High-Dose Dexamethasone in Relapsed MM: Efficacy Summary Efficacy of bortezomib was superior compared with dexamethasone in relapsed MM Treatment with bortezomib resulted in significantly greater time to progression, higher response rates, and improved survival Richardson P et al. Oral presentation at the 46th Annual Meeting of the American Society of Hematology; December 4–7, 2004; San Diego, California [abstract 336.5] * * * * * For VISTA EBMT* Response Criteria *European Group for Blood and Marrow Transplant Paraprotein: CR=100% reduction in serum urine; nCR=100% disappearance in serum urine; PR=≥50% reduction in serum ≥90% reduction in urine (or absolute value 200 mg/24hrs) Immunofixation CR= Negative; nCR= Positive; PR= Not required Bone Marrow: CR=5% plasma cells; nCR=5% plasma cells; PR=5% plasma cells Bone DiseaseCR= Stable or improvednCR= Stable or improved; PR= Stable or improved Plasmacytomas: CR= No plasmacytomas; nCR= No plasmacytomas; PR= Decreased by ≥50% Bladé et al. Br J Haematol 1998;102:1115-23 * * * CR, complete response; HR, hazard ratio; mos, months; MP, melphalan/prednisone; OS, overall survival; Pts, patients; VISTA, Velcade as Initial Standard Therapy in Multiple Myeloma: Assessment With Melphalan and Prednisone; VMP, Bortezomib/melphalan/prednisone; yr, year. * According to: Mateous et al. (Haematologica 2008; 93(4), 560-565) VMP is highly active and well tolerated in elderly patients with newly diagnosed multiple myeloma, with 85% of patients alive at 3 years. Moreover, VMP may overcome the poor prognostic impact of various factors, particularly cytogenetic abnormalities. * * * * * * * * * * * * Incidence of all grades reported. * * Incidence of all grades reported. * For fluid intake i.e. water, Ricelyte, Pedialyte, sports drinks, diluted fruit juices and broth. Loperamide (Imodium) 4 mg followed by 2 mg every 4 hours or after each unformed stool (maximum 16mg/day). May take 4 mg every 4 hours

文档评论(0)

该用户很懒,什么也没介绍

1亿VIP精品文档

相关文档