低钾型周期性瘫痪患者血钾浓度与肌力、心电图、肌酶水平关系分析.docVIP

低钾型周期性瘫痪患者血钾浓度与肌力、心电图、肌酶水平关系分析[摘要] 目的 探讨低钾型周期性瘫痪患者血钾浓度与肌力、心电图及肌酶水平的关系。 方法 选取来我院就诊的HOPP患者134例并分为A组（轻度低钾组，n=23），B组（中度低钾组，n=49），C组（重度低钾组，n=62）。 结果 三组上肢肌力及下肢肌力、血清肌酶升高率及血清肌酶水平差异有统计学意义（P0.05）。治疗后心电图P-R间期、QRS时限、Q-T间期低于治疗前（P0.05）。C组血清肌酶升高率、血清肌酶水平均高于A组及B组，B组高于A组（P0.05），血钾浓度与CK值呈现明显负相关（P0.05）。 结论 对HOPP患者血钾浓度降低的程度及其与肌力、心电图及肌酶水平之间的关系进行了解在疾病的诊断、治疗效果及预后的评估方面具有重要的作用。[关键词] 血钾；肌力；心电图；肌酶；低钾型周期性瘫痪[中图分类号] R746.1 [文献标识码] B [文章编号] 2095-0616（2015）01-207-03[Abstract] Objective To study the relationship between serum potassium concentration of hypokalemic periodic paralysed patients and muscle strength， electrocardiogram， and the levels of muscle enzymes. Methods 134 patients with HOPP who were selected in our hospital were divided into group A（mild hypokalemia group， n=23）， group B （moderate hypokalemia， n=49）， and group C（serious hypokalemia group， n=62）. Results The differences of upper extremity muscle strength， lower extremity muscle strength， the rising rate of muscle enzymes， and the levels of muscle enzymes between the three groups had statistical significance（P0.05）. The P-R interval， QRS duration， and P-T interval of electrocardiogram after treatment were lower than which of before treatment（P0.05）. The rising rate of muscle enzymes and the levels of muscle enzymes in group C were all higher than which in group A and group B， while which in group B was higher than which in group A（P0.05）. Serum potassium concentration and CK were statistical negative correlation.（P0.05）. Conclusion The understanding of the relationship between the degree of serum potassium concentration reduction of patients with HOPP and muscle strength， electrocardiogram， and the levels of muscle enzymes has important action on diagnosis， therapeutic efficacy， and prognostic evaluation.[Key words] Serum potassium； Muscle strength； Electrocardiogram； Muscle enzymes； Hypokalemic periodic paralysed低钾型周期性瘫痪（HoPP）是一种以发作性迟缓性骨骼肌瘫痪伴有血清钾水平降低为特征的疾病[1]，HoPP患者大部分在发生疾病时有典型的临床表现，诊断相对容易，如不采取措施及时治疗严重者会出现呼吸肌麻痹、心律失常对生命安全造成威胁，因此，及