Incidence of Acute Coronary Syndromes (ACS) St.PPTVIP

Incidence of Acute Coronary Syndromes (ACS): Statistics From Various Studies 1.4 million hospitalizations each year for ACS 944,000 hospitalizations for unstable angina; 1994 121,000 hospitalizations for non–Q-wave MI; 1994 ?60% patients with unstable angina 65 years old 46% of patients with unstable angina are women Clinical Trials of Unstable Angina and NQWMI: Short-Term Mortality Clinical Trials of Unstable Angina and NQWMI: Short-Term Risk of MI Ischemic Heart Disease: Time-Dependent Mortality Risk AGGRASTAT? (tirofiban HCl): Profile Indications for AGGRASTAT? (tirofiban HCl) AGGRASTAT, in combination with heparin, is indicated for the treatment of ACS, including patients who are to be managed medically and those undergoing PTCA or atherectomy. In this setting, AGGRASTAT has been shown to decrease the rate of a combined endpoint of death, new myocardial infarction or refractory ischemia/repeat cardiac procedure. Contraindications for AGGRASTAT ? (tirofiban HCl) AGGRASTAT is contraindicated in patients with: Known hypersensitivity to any component of the product Active internal bleeding or a history of bleeding diathesis within the previous 30 days History of intracranial hemorrhage, intracranial neoplasm, arteriovenous malformation, or aneurysm History of thrombocytopenia following prior exposure to AGGRASTAT History of stroke within 30 days or any history of hemorrhagic stroke Major surgical procedure or severe physical trauma within the previous month History, symptoms, or findings suggestive of aortic dissection Severe hypertension (systolic blood pressure 180 mmHg and/or diastolic blood pressure 110 mmHg) Concomitant use of another parenteral GP IIb/IIIa inhibitor Acute pericarditis Clinical Program for AGGRASTAT ? (tirofiban HCl) in UAP/NQWMI PRISM-PLUS: Entry Criteria 1915 patients with UAP or NQWMI randomized Entry criteria Prolonged anginal pain or repetitive episodes of angina at rest or during minimal exercise in previous 12 h and New transient o