HPLC法测定人唾液中卡马西平浓度及其药代动力学.docVIP

HPLC法测定人唾液中卡马西平浓度及其药代动力学 作者：唐哲，文爱东，吴寅，赵磊，李宏力，石茹 【关键词】 卡马西平 Determination of carbamazepine concentration in human saliva by HPLC and its pharmacokinetic study 【Abstract】 AIM: To determine carbamazepine concentration in human saliva by HPLC and study its pharmacokinetics. METHODS: Shimpack CLCODS C18 spectrum analytical column was used and methanolwaterwas adopted as the mobile phase. Flow rate was mL?min-1, detection wavelength was 212 nm, column temperature was 23℃ and the dosage of CBZ was 50 μL. The pharmacokinetic paramete