11～13+6周系统超声检查对胎儿神经系统畸形的诊断价值.docVIP

11～13+6周系统超声检查对胎儿神经系统畸形的诊断价值 　　【摘要】 目的：探讨早孕期超声检查对胎儿神经系统畸形的诊断价值。方法：选取2011年1月-2013年4月来本院行早孕期胎儿系统超声检查的孕妇共3492例。对11～13+6周胎儿行胎儿系统超声检查，除测量胎儿头臀长、NT及静脉导管的检测外，并对胎儿神经系统畸形进行筛查，基本引用中孕期颅脑超声检查的标准切面，严重神经系统畸形胎儿建议胎儿父母选择终止妊娠。余神经系统阴性病例继续妊娠，行中晚孕期系统超声检查并追踪其妊娠结局及引产结果。结果：早孕期系统超声检查共筛查出神经系统畸形10例（0.29%），包括露脑、无脑畸形9例（同时合并开放性脊柱裂4例），全前脑1例。早孕期正常，中晚孕期超声神经系统异常或中晚孕期超声正常，但新生儿神经系统异常的有4例（0.11%），包括蛛网膜囊肿2例，脑积水1例，一侧侧脑室扩张1例。结论：早孕期11～13+6周胎儿系统超声检查可以筛查出部分早期发生的胎儿神经系统异常，对早期诊断胎儿神经系统的严重畸形有重要意义，但仍不能替代中晚孕期胎儿的超声检查，因此将二者联合起来，可以较好地筛查胎儿神经系统畸形。 　　【关键词】 11～13+6周； 系统超声检查； 胎儿； 神经系统畸形 　　中图分类号 R445.1 文献标识码 A 文章编号 1674-6805（2014）14-0050-03 　　The Value of First Trimester Screening with Ultrasound in the Detection of Nerve System Malformation/ZHOU Xue，WANG Chun-lian，LI Zheng-bin.//Chinese and Foreign Medical Research，2014，12（14）：50-52 　　【Abstract】 Objective：To evaluate the value of first trimester screening with ultrasound in the detection of nerve system malformation.Method：3492 pregnant women undergoing first trimester screening with ultrasound from January 2011 to April 2013 were enrolled in this study.The pregnancy outcome was recorded，11-13+6 weeks fetal was given ultrasound system，in addition to the measurement of fetal crown-rump length，fetal crown-rump length，NT and venous catheters detection.Nerve system malformation was screened in accordance with the standards of the mid-trimester ultrasound section.The fetuses with major abnormalities were terminated according the choice of the parents after consultation.Result：Among the 3492 fetuses，10（0.29%） fetuses were diagnosed with nerve system malformations，including 9 fetuses with anencephaly and spina bifida，1 fetuses with full forebrain 4（0.11%） fetuses were diagnosed with nerve system malformations in the first trimester，including 2 cases with arachnoid cyst，1 case with hydrocephalus，1 case of lateral ventricle dilatation.Conclusion：Although the first trimester （11-13+6 weeeks） screening with ultrasound could detect the fetuses with major malformations，it can no