奈达铂联合亚叶酸钙和氟尿嘧啶治疗中晚期食管癌的临床观察.docVIP

奈达铂联合亚叶酸钙和氟尿嘧啶治疗中晚期食管癌的临床观察 　　【摘 要】目的：观察奈达铂（NDP）联合亚叶酸钙（CF）和氟尿嘧啶（5Fu）治疗中晚期食管癌的近期疗效及毒副反应。方法：63例晚期食管癌患者分为治疗组（31例）和对照组（32例）。治疗组给予NDP联合CF和5Fu治疗；对照组给予顺铂（DDP）联合CF和5Fu治疗。结果：治疗组和对照组的总有效率分别为45.2%和43.8%（P0.05）。中位疾病进展时间（TTP）分别为8.2个月和8.0个月（P0.05）。治疗组白细胞减少发生率与对照组相近（P0.05 ），血小板减少发生率显著高于对照组（P=0.042），贫血，口腔炎，脱发，外周神经毒性的发生率均与对照组相近（P均0.05）；Ⅲ～Ⅳ度恶心呕吐，腹泻，肾毒性等毒副反应发生率均显著低于对照组（P均0.05）。结论：奈达铂联合亚叶酸钙和氟尿嘧啶治疗中晚期食管癌，疗效较好，且毒副作用较小，可作为一线化疗方案。 　　【关键词】食管癌；奈达铂；亚叶酸钙；氟尿嘧啶；化疗 　　【中图分类号】R57 【文献标识码】B 【文章编号】1004-7484（2013）05-0034-02 　　Clinical Study of Nedaplatin Combination with Calcium Folinate and Flrorouracil in Treatment of Advanced Esophageal Carcinoma 　　YANG Yu-xian ， CHEN zhi-ming， ZHANG Sheng-qi， ZHUANG Xiao-wen，QIU Xi-hui 　　（Dept.of Oncology， Tumor Hospital of Shantou University Medical College， Shantou Guangdong 515031，China） 　　【Abstract】Objective：To evaluate the efficacy and toxicity of nedaplatin in combination with calcium folinate and flrorouracil in treatment advanced esophageal carcinoma. Methods：63 patients with advanced esophageal cancer were divided into treatment group （31 cases）and control group（32cases）.Treatment group was given nedaplatin combined with calcium folinate and Flrorouracil in therapy； control group was given cisplatin and calcium folinate and flrorouracil in therapy. Results：The overall response rate was 45.2%in the treatment group and 43.8% in control group （P0.05）. The median time to progression （TTP） was 8.2 months vs.8.0 months（P0.05）.Compared with control group， the treatment group，s side effects of neutropenia were not significant difference（P0.05）.， while the thrombopenia was higher （P=0.042）. anemia，stomasitis ， alopecia and peripheral nerve toxicity were not significant difference （P0.05）， while grade Ⅲ～Ⅳ nausea and vomiting，diarrhea and renal toxicity were lower（P0.05）. Conclusion：The effect of nedaplatin combined with calcium folinate and flrorouracil have satisfactory effect in the treatment of advanced esophageal carcinoma， and the poisonous side effe