纳洛酮在急性有机磷中毒中的综合应用价值研究.docVIP

纳洛酮在急性有机磷中毒中的综合应用价值研究 　　[摘要] 目的 观察纳洛酮在急性有机磷中毒中的综合应用价值。 方法 选取2010年9月～2013年4月于本院进行治疗的82例急性有机磷中毒患者为研究对象，将其随机分为对照组（常规治疗方案组）41例和观察组（常规治疗方案加纳洛酮组）41例，对两组中轻度、中度及重度患者的临床总有效率、阿托品化时间、阿托品用量及症状改善时间进行比较。 结果 观察组的轻度、中度及重度患者的临床总有效率均高于对照组，阿托品化时间、阿托品用量及症状改善时间也明显低于对照组，差异均有统计学意义（P0.05）。 结论 纳洛酮在急性有机磷中毒中的综合应用价值较高，效果好且显效快。 　　[关键词] 纳洛酮；急性有机磷中毒；综合应用价值 　　[中图分类号] R595.4 [文献标识码] A [文章编号] 1674-4721（2013）07（a）-0074-02 　　Study on the comprehensive application value of Naloxone in patients with acute organophosphorus poisoning 　　GAO Feng-ling 　　The Health Center of Liuli Town of Huairou Area in Beijing City，Beijing 101407，China 　　[Abstract] Objective To study and observe the comprehensive application value of Naloxone in patient with acute organophosphorus poisoning.Methods Eighty two patients with acute organophosphorus poisoning in our hospital from September 2010 to April 2013 were selected as research object，and were randomly divided into control group （conventional treatment group） 41 cases and observation group （conventional treatment and Naloxone group） 41 cases，then the clinical effective rate，atropinization time，dosage of atropine and improvement time of symptom of two groups with mild，moderate and severe poisoning were compared.Results The clinical effective rate of observation group with mild，moderate and severe poisoning were all higher than those of control group，atropinization time，dosage of atropine and improvement time of symptom were all obviously lower than those of control group too，there were all significant differences （P0.05）.Conclusion The comprehensive application value of Naloxone in patients with acute organophosphorus poisoning is higher，the effect is better and faster. 　　[Key words] Naloxone；Acute organophosphorus poisoning；Comprehensive application value 　　急性有机磷中毒对患者造成的危害较大，甚至可危及患者的生命安全，另外，本类患者要做到早期性及有效性，以尽量改善患者预后，因此对于治疗用药方案的评估条件不仅仅包括其最终治疗效果，也包括显效的速度等。近些年来临床中采用纳洛酮应用于本病的治疗，效果较肯定，但是对其综合且全面价值的研究仍相对缺乏，因此值得更为全面及细致地探讨[1]。本文就纳洛酮在急性有机磷中毒中的综合应用价值进行观察。 　　1 资料与方法