成年人超重和肥胖对血尿酸水平的影响.docVIP

成年人超重和肥胖对血尿酸水平的影响 　　摘 要：目的： 探讨成年人超重和肥胖对血尿酸水平的影响。方法： 选择来我院疗养和体检的18岁以上成年人2262例作为研究对象，按体重指数分层后，设置正常体重组1224例，超重和肥胖组1038例，分别观察两组成年人的血尿酸水平（UA）、血压（SBP/DBP）、 空腹血糖（FPG）、血甘油三酯（TG）、血总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）；统计两组成年人高尿酸血症、高血压病、2型糖尿病、高血脂、脂肪肝和冠心病的患病率，分析超重和肥胖与血尿酸水平及其他心血管疾病危险因素的相关性。结果 ：超重和肥胖组成年人血尿酸水平、血压（SBP/DBP）、 空腹血糖、血甘油三酯、血总胆固醇、低密度脂蛋白均值均高于正常体重组，高密度脂蛋白低于正常体重组，差异有统计学意义（P0.01）； 超重和肥胖组成年人的高尿酸血症、高血压病、2型糖尿病、高血脂、脂肪肝和冠心病的患病率均高于正常体重组（P0.01）；相关分析显示，成年人超重和肥胖与血尿酸水平及其他心血管疾病危险因素呈明显正相关。结论： 成年人超重和肥胖与血尿酸水平升高及心血管疾病密切相关，是心血管疾病的重要危险因素之一。 　　关键词：超重和肥胖；血尿酸水平；心血管疾病；危险因素 　　Abstract：Objective To investigate the influence of over weight and obesity in the adult persons on uric acid.Methods 2262 case in the adult persons aged over 18 who were examined in our sanatorium were selected according to body weight index. There were 1224 cases in normal body weight group . There were 1038 cases in over weight and obesity group. Then we observed blood uric acid ，blood pressure（SBP/DBP）， blood glucose， triglyceride， total cholesterol， HDL and LDL of the two groups in the adult persons. The prevalence rates of the hyperuricemia， hypertension， diabetes， dyslipidemia， fatty liver and coronary heart disease were calculated and analyzed in the two groups in the adult persons. The relationship between over weight and obesity in the adult persons and blood uric acid and risk factors of cardiovascular disease were analyzed. Results The blood uric acid ，blood pressure （SBP/DBP）， blood glucose， triglyceride， total cholesterol and LDL were significantly higher in over weight and obesity group than in normal body weight group （P0.01）. The prevalence rates of hyperuricemia， hypertension， diabetes， dyslipidemia， fatty liver and coronary heart disease were significantly higher in over weight and obesity group in the adult persons than in normal body weight group（P0.01）.The over weight and obesity in the adult persons was positively corretated with the blood uric acid and risk factors of cardiovascular disease. Conclus