QTL定位的原理和方法教案.ppt

Combined LD-LA mapping Authors investigating the extent of LD in both cattle and sheep were somewhat surprised/alarmed to find not only was LD highly variable across any particular chromosome, but there was even significant LD between markers which were not even on the same chromosome! * Combining method If the common ancestor occurs within the known pedi-gree, then IBD probability can be calculated from the markers by linkage analysis (LA) If the common ances-tor is outside the known pedigree it is a source of LD.In this case the probability that the QTL alleles are IBD is calculated from th