Clinical Grant Writing Pearls and Pitfalls临床上写的珍珠和陷阱.ppt

Clinical Grant Writing:Pearls and Pitfalls James D. Lewis, MD, MSCE University of Pennsylvania Is the Clinician Researcher a Dying Breed? Human Studies Received Lower Priority Scores Review Panel Experience – Little Evidence of Bias Where Do Clinical Applications Go Wrong? Aims Background Preliminary studies Methods Limitations section Abstract Specific Aims Only sections that most panel members will read (if they even read these) Sell the whole story in a few paragraphs State your hypothesis, aims, and design Specific Aims Need To Be Specific Identify risk factors for exacerbation of Crohn’s disease Vague To determine whether consumption of non-aspirin NSAIDs is associated with exacerbation of Crohn’s disease Specific What Does This Have To Do With Grant Writing? A Hypothesis Is Essential P01, R01, K08, K23, K01 Hypothesis testing is essential R03 Hypothesis testing preferred Also fundable Proof of principle Feasibility Hypothesis generation? Aims Must Be Achievable Background Section Background Section Tell a story - Not a review article Refer to your prior work if appropriate Selected references Demonstrate your knowledge of the field Reviewers’ articles? Conclusion of background section – Need for your proposed study is obvious!!! Preliminary Studies Support for your hypothesis Present your background research that led to current hypothesis Feasibility Required data available Study population available Measurement tools accurate / responsive You and your team’s qualifications Sell Yourself Dr. Smith is an Assistant Professor of Medicine at XYZ University. She has a master’s degree in Clinical Epidemiology from ABC Univ. She has more than X years experience in caring for patients with IBD and conducting research in the field. Her previous research experience includes … (refs). Of particular relevance to this application, she … Methods Section Methods Section Details essential Address each aim Inclusion / Exclusion criteria Data collection Analyses Potential li