COCONUT OIL ALZHEIMER’S DISEASE椰子油和阿尔茨海默氏病.ppt

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Drs. George Cahill, Mary Newport Richard Veech in Capitol Building – March 2009 KETOGENIC DIET History Fasting used as treatment for seizures and epilepsy in biblical times and middle ages Early 1900’s - NY Pediatrician Rawle Geyelin successfully fasted children to control seizures (15 day fast) – 18% were helped 1921 – Wilder proposed that benefits of fasting (increase in ketone bodies) could be produced by diet rich in fats and low in carbohydrates - - “ketogenic diet” KETOGENIC DIET History (continued): 1924 – Peterman reports effectiveness of diet from Mayo Clinic – 51% seizure free after 2 ? years on diet 1 gram protein per kg body weight 10-15 grams/day carbohydrate Remainder of calories as fat Total calories Basal Metabolic Rate + 50% Identical to ketogenic diet used today – some variations exist – including MCT oil version – half of calories are MCT oil KETOGENIC DIET Reported positive effects of ketogenic diet: Epilepsy Alzheimer’s disease Parkinson’s disease Lou Gehrig’s disease (ALS) Traumatic brain injury and stroke Oxygen toxicity Glioblastoma and other cancerous tumors Weight loss Brain Metabolism during Fasting 0. E. OWEN, A. P. MORGAN, H. G. KEMP, J. M. SULLIVAN, M. G. HERRERA, AND G. F. CAHILL, JR. The Journal of Clinical Investigation Vol. 46, No. 10, 1967 First report of ability of brain to use ketones as fuel Diagram from: Ketone Bodies as a Fuel for the Brain during Starvation - Oliver E. Owen?BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATIONVol. 33, No. 4, pp. 246–251, 2005 Overnight in normal people: glucose 100% of fuel Starvation: Ketones about 2/3 of fuel Diagram from: Ketone Bodies as a Fuel for the Brain during StarvationOliver E. Owen?BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATIONPrinted in U.S.A. Vol. 33, No. 4, pp. 246–251, 2005 FIG. 3. Concentrations of ketone