0609-放疗科-外照射、热疗及超激光对荷vx2瘤兔tnf、igf、ca-50的影响.doc

外照射、热疗及超激光对荷VX瘤兔TNF、IGF、CA-50的影响 E ffects of teletherapy， caled hypertherm ia and SUPER LIZER on VX rabbitsTNF，IGF，CA-50《现代》200年第期LIU Jian-guo，HAN Qiu-ju，YU Ji-weiDepartment of Radiation Oncology， Datong Rail way Central Hospital ， Datong037005， China【摘要】目的瘤兔的治疗作用，及其细胞因子的改变情况。 方法结果结论种植成功后对宿主细胞免疫产生明显的抑制作用。外照射对其疗效明显好于热疗，且较明显地改变其免疫过程。超激光治疗对VX瘤治疗无效。 【Abstract】　Objective: To observe teletherapy ， localed hyperthermia and SUPER LIZER effects on VX carcinoma rabbits lytokines .M ethods: Eighty male white health rabbitswere selected， and divided into four groups 20 for each.Tumorsdiameter， time of survivalwere observed and changes of TNF， IGF， CA-50 before and afterVX2carcinoma replanted and treated after one， three， fourweekswere examined.Results:The diameters of tumors and time of survival from large(short) to small( long) in orderwere group， comparison group， hyperthermia group and teletherapy group.AfterVX2carcinoma replanted TNF， IGF，CA-50 increased. Afterbeing treated fourweeksTNF，IGF，CA-50 increased in othergroups.Therewas no significantdifference between super lizergroup and comparison group(P0.05)， but therewas significantdifference between the obove two groups and hyperthermia group or teletherapy group(P0.01).Conclusion:VXcarcinoma replanted obviously changes cells immunity. The treated effect of teletherapy is better than hyperthermia. Teletherapy can obviously change the course of immunity. SUPER LIZER have no effect on VXcarcinoma. 【关键词】；瘤细胞因子 【Key words】radiotherapy；teletherapy；hyperthermia；SUPER LIZER；VX；carcinoma lytokine VX瘤是Shope病毒诱发的乳头状瘤恶变后经兔传代而取得的实验性肿瘤，近似于人的实质器官原发恶性肿瘤，将其接种于兔的各个部位进行动物实验研究模型的制作，迄今有报道[1，2]。关于外照射、热疗及超激光对荷VX瘤大白兔治疗作用的对比性观察在国内未见报道。现将我们的实验情况报道如下。 材料与方法 ：~12天，实验动物均可触及(2.5~3)cm的肿瘤，为种植成功。 治疗与方法：外照射采用SIEMENS PRIMUS-M直线加速器产生的6MV-X射线，将野中心对准兔右腿处肿瘤采用SSD照射，野边界在肿瘤边缘外放(3~5)cm，照射剂量200cGy/F，DT2000cGy/10F/20d。常规分割治疗，将动物固定于木板之上。 热疗采用珠海产的HG-2000型体外高频热疗机，输入电压220V，温度控制在42.5℃~43.0℃，机控输入功率在90%~95%，计算机控制其与温度相关，大于此值温度达45℃，小于此值温度低于42℃。每次热疗10min，1次/d，共15d。 超激光设备