impact of perioperative dexamethasone on postoperative.pptVIP

Impact of perioperative dexamethasone on postoperative analgesia and side-effects: systematic review andmeta-analysis Backgroud 研究背景 Backgroud Glucocorticoids have been used to reduce in?ammation and tissue damage in a variety of conditions, including in?ammatory bowel disease, rheumatoid arthritis, and some malignancies. Glucocorticoids have potent immunomodulatory effects, and are used in the treatment of acute allograft rejection. They also have antiemetic properties and dexamethasone is commonly used for the prevention of postoperative nausea and vomiting (PONV) Backgroud The efficacy of glucocorticoids for reducing pain and infiammation after surgery has recently been explored. Early studiesin patients undergoing dental procedures showed that glucocorticoids were effective in reducing postoperative pain andoedema. A number of recent studies have investigated the potential analgesic bene?t of a single perioperative dose of dexamethasone but Have inconsistent?findings. Backgroud Long-termtreatment with glucocorticoids is Associated with many side-effects. However, it is unclear if a single perioperative dose of dexamethasone increases the risk of these adverse effects. This is due to many of the published studies being underpowered to detect clinically relevant sideeffects, and many studies also excluded patients at thehighest risk of glucocorticoid-related adverse effects. Backgroud We therefore performed this systematic review to determine if a single perioperative dose of dexamethasone in adult surgical patients undergoing surgery under general anaesthesia has a useful analgesic effect in the postoperative period. We also investigated whether the use of dexamethasone increases the risk of postoperative adverse effects. Methods 研究方法 Methods We followed the recommendations of the PRISMA Statement in creating this review.The data