围术期自体富血小板血浆分离技术的临床应用.ppt

DUAL SYRINGE APPLICATOR双排加样注射器 FIBRIN SEALANT ACTIVATION MECHANISM 纤胶激活原理 Thrombin 凝血酶 Fibrinogen 纤原 Fibrin Monomer (soluble) 纤维蛋白单体 (可溶性) Factor XIII Ca+ 八因子和钙离子 Fibrin Polymer (insoluble) 纤维蛋白多聚体 (不可溶) Fibrinolytic Degradation降解 Fibrin Sealant Indications 纤胶的应用 Hemostasis 止血 Drug Delivery 药物载体 Sealant 封闭 Reduced Hemorrhage 减少出血 Coagulation Disorders 凝血障碍 Heparinized Procedures 肝素化过程 FIBRIN SEALANT (U.S. basic commercial)纤胶(美国市场) 1. Safety 安全性 Pooled Human Plasma人类血浆 Pooled Human Thrombin人血源凝血酶 Virally Inactivated病毒灭活 Bovine Aprotinin牛抑肽酶 Biodegradable可生物降解 FIBRIN SEALANT (U.S. basic commercial) 纤胶(美国市场) Efficacy 效用 Approved Indications:已证明的应用 Hemostasis止血 Cardiac Surgery心脏手术 Splenic Trauma脾外伤 Sealant伤口愈合 Colonic Anastomoses 结肠修复 FIBRIN SEALANT (alternatives)纤胶(其它来源) Blood bank products 血库产品 Laboratory products 实验室产品 Collagen enhanced products 改良的胶原产品 Platelet gels 血小板胶 FIBRIN SEALANT APPLICATIONS 纤胶用途 Many specialties:许多特殊用途 ? Thoracic and Cardiovascular 胸心外科 ? Neurologic 神经外科 ? Plastic 整形外科 ? Otolaryngology 耳鼻咽科 ? Orthopaedic 骨科 ? Ophthalmologic 眼科 ? Trauma 外伤 ? Urologic 泌尿外科 ? Gynecologic 妇科 ? Transplant 移植 ? General 普外科 ? Vascular 血管外科 As of June 30th, 2000. The following Tissue Adhesives have gained FDA approval. Fibrin Sealant Cyanoacrylate Collagen and Thrombin Peg Polymer Albumin and Gluteraldehyde We begin with Fibrin Sealant— Composed of Virally inactivated pooled human plasma with a fibrinogen concentration 75-115 mg/ml And Human Thrombin at 500 u/ml The current products include a Bovine component of Aprotinin at 3,000 u/ml and theoretically carry the risk of antibody formation. Fibrin Sealant is biodegradable mimicking the process of natural tissue healing over the course of a week. Fibrin sealant is approved as an adjunct to hemostasis in cardiac surgery and procedures to repair splenic injury due to blunt or p