脊柱关节炎早期诊断新进展课件.pptVIP

脊柱关节炎早期诊断新进展 CT, MR在早期诊断中的应用 12岁B27+男孩的早期右骶髂关节炎 AS发病机制的新观点 与AS发病相关的基因产物之间的相互关系 AS肌腱端炎的病理学 B27分子的3种不同结构及其诱发AS的可能过程 欢迎索阅并积极参与讨论、竟猜 Figure 3: Hypothetical functional interactions between gene products associated with ankylosing spondylitis. The genes HLA-B27, ERAP1, IL23R, IL1R2, TRADD, TNFR1, CARD9, and ANTXR2 (not shown) have definite or suggested associations with AS. One mechanism linking HLA-B27 to the IL-23/IL-17 (TH17) axis involves misfolding and UPR activation triggered by MHC class I upregulation. UPR activation enhances production of IL-23 and IFN-β in response to certain PRR agonists