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复方辛夷滴鼻液的制备工艺及疗效观察复方辛夷滴鼻液的制备工艺及疗效观察
复方辛夷滴鼻液的制备工艺及疗效观察
黄玉芍 赵文斌 (云南省中医医院 云南昆明 650021)
关键词:鼻炎 复方辛夷滴鼻液 制备工艺 疗效中图分类号:R283,R276.1 文献标识码:C 文章编号:1008-0805(2003)01-0015-01
The curative effect,preparation And technology of Compound Xinyi Nose Drop
Huang Yushao、Zhao Weibing(Yun Nan College of Chinese traditional medicine,Kun Ming、Yun Nan)Liao Xiao Zhong Tu Fen Lei Hao:R283;R276、1 ,The mark of this document:C ,The number of this article:1008—0805(2003)01—0015—0 1
It is common to see chronic rhinits,allergic coryza、sinusitis clinically。The trend of morbid rate is still upwards recently,which because of the environmental pollution becomes more and more serious,and there is on specific herbs can cure it now。The heavy side—effect of some western medicine can cause drug—induced nasitis。The Effect of some Chinese medicinal herbs which are to be taken orally is not good as we expected。Because of its low density, the writer developed a kind of medicine named Compound Xinyi Nose Drop from long—term use of prescription which was to be taken orally of our ear—nose—throat department,it really can clear away heat and remove poison、activate blood to connect with aperture、let the pus out and produce the muscle。Having been used party more than 4a clinical observation and experiment on the effect of it,it has been proved to have a good effect。
Key Words: Rhinitis; Compound Xinyi Nose Drop
慢性鼻炎、过敏性鼻炎、鼻窦炎是临床常见多发病,且随着环境污染日趋严重,发病率有上升趋势,目前尚无特效药物治疗。一些西药制剂副作用较大易造成药物性鼻炎;内服中药局部药物浓度不高而效果不理想。笔者在我院耳鼻喉科长期使用的有效内服处方的基础上研制出具有清热解毒、活血通窍、排脓生肌功效的中药复方滴鼻剂一复方辛夷滴鼻液。作为局部用药,经4a多的临床观察及药效学试验证实,该药疗效良好。
1 制备工艺
1.1 处方: 辛夷80g,紫丹参60g,鱼腥草80g,苍耳子120g,鹅不食草120g,ATP5g,山梨酸lg,吐温-8010ml,氯化钠6g.
1.2 制法:取以上5味中药以蒸馏法收取挥发油饱和溶液约600ml,加吐温-80搅匀备用;残渣加水煎煮2次,lh/次。过滤,合并滤液,浓缩至相对密度1.10~1.20(60oC)口乙醇使含醇量为70%,冷藏24h,取上清液回收乙醇至无醇味,得药液约100ml与蒸馏液混合,加山梨酸(适量乙醇溶解)、氯化钠、ATP使溶,调pH至规定范围,抽滤,添加蒸馏水至1000ml即得。
2 质量控制
2.1 性状本品为浅棕红色至棕红色透明液体,气辛香。
2.2 鉴别
2.2.1 辛夷取本品30ml加氯仿30ml振摇5min,放置,分取氯仿层,挥至2ml,作为供试品溶液,另取辛夷对照药材4g,于50℃水浴温浸1h,过滤,取滤液挥至2ml作为对照药材溶液;另取除辛夷制成的阴性对照液30ml以下同样品液操作得2ml,作为阴性对照液,吸取上
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