MHC(MajorHistocompatibilityComplex).pptVIP

Part V. Interaction of HLA molecules and antigen peptides Combination of antigen peptide and antigen-binding groove Molecular basis of the interaction of HLA molecules and antigen peptides Characteristics of MHC molecules-antigen peptides interaction 1. Combination of antigen peptide and antigen binding groove 肽槽 a 螺旋 肽槽 MHC-I 分子 MHC-II 分子 NH2 NH2 COOH （衔接 b2） a2 COOH（衔接 a2） a1 b1 a 螺旋 a 螺旋 a1 a 螺旋 COOH （衔接 a3） NH2 Class I MHC molecule A peptide 8-10 amino acids long sits in the groove. The greatest variability in amino acids occurs in the ?1 and ? 2 sequences Class II