(精)chapter+30-33+nitrogen+metabolism-2.ppt

3.2.4 核糖三磷酸和胸苷酸的生物合成 核苷酸与核酸生物合成的关系 PRPP酰胺转移酶：受IMP、AMP和GMP的抑制，受PRPP的激活 腺苷酸代琥珀酸合成酶 次黄嘌呤核苷酸脱氢酶 从头合成和补救合成途径之间的调控 嘌呤核苷酸合成关键酶的调控 3.3 核苷酸生物合成途径的调控 天冬氨酸氨基甲酰转移酶(ATCase)：是细菌中的关键调控酶，受ATP的变构激活，受CTP、UTP抑制 氨甲酰磷酸合成酶（CPS-Ⅱ）：是动物细胞的关键调控酶，受ATP和PRPP激活，受UDP和UTP抑制 嘧啶核苷酸合成关键酶的调控 The biosynthesis of AMP and GMP is regulated by feedback inhibition PRPP synthase and glutamine-PRPP amidotransferase are both inhibited by the end products IMP, AMP and GMP (AMP and GMP act synergistically). AMP inhibits adenylosuccinate synthase and GMP inhibits IMP dehydrogenase. AMP and GMP synthesis is balanced by the following mech