口服益生菌预防极低出生体质量儿坏死性小肠结肠炎的临床观察..docVIP

口服益生菌预防极低出生体质量儿坏死性小肠结肠炎的临床观察 王羲之（广州医科大学） [摘要] 目的 探讨口服益生菌预防极低出生体质量儿（VLBWI）坏死性小肠结肠炎(NEC)的临床效果及安全性。方法 92例VLBWI随机分为两组，对照组46例给予综合治疗；治疗组46例在此基础上给予口服益生菌，0.25 g,3次／d,连用21 d。结果 治疗组患儿NEC的发生率较对照组低（4.35﹪vs 21.74﹪），达完全肠内营养时间明显较对照组短，差异有统计学意义（P＜0.05）；但严重NEC的发生率及病死率、脓毒症发生两组相比，差异无统计学意义（P＞0.05）。结论 益生菌可以降低VLBWI NEC的发生率，缩短其达完全肠内营养时间，其临床应用是相当安全的。 [关键词]极低出生体质量儿；坏死性小肠结肠炎；益生菌 Clinical observation of oral probiotics on the prevention of necrotizing enterocolitis in very low birth weight infants Li Yingying，Huang Qiling,Zhu Feng, et al Department of Neonatology, Suzhou Municipal Hospital, Suzhou Hospital of Anhui Medical University,Suzhou 234000,China [Abstract] Objective:To investigate the clinical efficacy and safety of the prevention of necrotizing enterocolitis in very low birth weight infants by oral probiotics. Methods:92 very low birth weight infants were divided into two groups randomly.46 very low birth weight infants in control group were preformed with combined therapy.On this basis,46 cases in treatment group were preformed with probiotics 0.25 g,po,tid,the course of treatment was 21 days. Results:The incidence of NEC in the treatment group was lower than that in the control group（4.35﹪ vs 21.74﹪）,The time to reach full enteral nutrition in the treatment group were shorter than those in the control group,there were significant difference（ P＜0.05）. The incidence of severe NEC and mortality or the incidence of pyohemia between two groups, there were no significant difference（P＞0.05）.Conclusions:Probiotics can reduce the incidence of NEC in very low birth weight infants，can shorten the time to reach full enteral nutrition.The application of probiotics appears to be safe in very low birth weight infants.This approach is worth promoting for hemorrhage clinicaluse. [Key words] Very low birth weight；Necrotizing enterocolitis；Probiotics 新生儿坏死性小肠结肠炎(necrotizing enterocolitis of newborn,NEC)是极低出生体质量儿(very low birth weight infants,VLBWI)最常见的并发症之一。国外文献报道，出生体质量500～1500 g早产儿NEC患病率为7％，病死率高达