三七总皂苷、黄芪对2型糖尿病动脉粥样硬化大鼠修饰型低密度脂蛋白的影响.docVIP

三七总皂苷、黄芪对2型糖尿病动脉粥样硬化大鼠修饰型低密度脂蛋白的影响 nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; 作者：李静波，刘宽芝，李金荣 【摘要】nbsp; 目的 探讨三七总皂苷、黄芪防治2型糖尿病动脉粥样硬化的作用机制。方法 建立2型糖尿病大鼠模型，随机分为糖尿病模型组及糖尿病三七总皂苷、黄芪治疗组，并与正常对照组比较，分别测定各组大鼠血糖、血脂、氧化及糖化低密度脂蛋白水平，并取大鼠主动脉组织进行形态学观察，计算病灶面积与管壁总面积比值。结果 2型糖尿病大鼠血糖、甘油三酯（TG）、总胆固醇（TC）、极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）、氧化低密度脂蛋白（Ox-LDL）和糖化低密度脂蛋白（Gly-LDL）水平升高，高密度脂蛋白（HDL）下降，主动脉病变程度明显。三七总皂苷、黄芪治疗组动物各项指标均有明显改善。结论 三七总皂苷、黄芪可通过降低血糖、调节血脂、抗氧化发挥其防治2型糖尿病AS的作用。 【关键词】nbsp; 三七总皂苷；黄芪；氧化低密度脂蛋白；糖化低密度脂蛋白；动脉粥样硬化；2型糖尿病 nbsp;nbsp;nbsp; 【Abstract】nbsp; Objectivenbsp; To investigate the role and mechanism of Astragalus (AS) and Panax Notoginseng Saponins (PNS) in treatment of type 2 diabetic atherosclerosis. Methodsnbsp; Type 2 diabetic rats induced by high-fat diet and a low dose of STZ were divided into two groups randomly: diabetic model rats group treated with AS and PNS as compared with control subjects. Serum level of oxidized low density lipoprotein (Ox-LDL), Glycated low density lipoprotein (Gly-LDL), lipid and blood glucose were measured before and after treatment. Aorta tissue was stained with HE and observed with microscope.Resultsnbsp; The serum levels of GLU, TG, TC, LDL-C, VLDL-C, Ox-LDL and Gly-LDL in type 2 diabetic rats were improved, while the levels of HDL-C were decreased. The pathological changes of aorta tissue were obvious in diabetic rats. Each index was improved after treatment with AS and PNS. Conclusionnbsp; tPNS and Ast can reduce the level of glucose, regulate the serum lipids, antagonize oxidation, thus the two Chinese herbs may prevent and cure diabetic atherosclerosis. nbsp;nbsp;nbsp; 【Key words】nbsp; Total panax notoginseng saponins; astragalus membranaceus; oxidized low density lipoprotein; Glycated low density lipoprotein; atherosclerosis; type 2 diabetes nbsp;nbsp;nbsp; 大血管病变是2型糖尿病（DM）的常见并发症，严重威胁着人类的健康，其突出的病理变化是动脉粥样硬化（AS）。近年研究表明，修饰型