左旋甲状腺素治疗亚临床甲减、临床甲减的疗效观察.docVIP

左旋甲状腺素治疗亚临床甲减、临床甲减的疗效观察 　　[摘要] 目的 探讨左旋甲状腺素治疗亚临床甲减、临床甲减的临床疗效及对患者血脂水平的影响。 方法 选取144例甲状腺功能减退患儿作为研究对象，按照就诊顺序将其随机分为两组，每组为72例，两组患者均给予降糖、控压、扩张冠状动脉等常规对症治疗，观察组给予左旋甲状腺素钠，比较两组患者治疗前后甲状腺激素水平和血脂水平变化。结果 观察组治疗后FT3、FT4和TSH水平分别为（6.77±0.72）pmol/L、 　　（13.56±1.52）pmol/L和（3.25±1.20）mIU/L，均较治疗前和对照组明显改善;而TC和TG水平分别为（4.15±0.88）mmol/L和（1.65±0.32）mmol/L，均较治疗前和对照组显著降低，且两组比较差异均具有统计学意义（P0.05）。 结论 左旋甲状腺素治疗亚临床甲减、临床甲减疗效显著，可明显改善患者甲状腺功能，降低血脂水平，具有较好的临床应用和推广价值。 　　[关键词] 左旋甲状腺素;亚临床甲减;临床甲减 　　[中图分类号] R581.2 [文献标识码] B [文章编号] 2095-0616（2015）02-51-03 　　Observation of the clinical efficacy of subclinical hypothyroidism， 　　clinical hypothyroidism treated with levothyroxine 　　ZHANG Silu1 WEI Haiyan1 GU Qianru2 CHEN Yongxing1 LIU Xiaojing1 　　1.Genetic Endocrinology and Metabolism， Childrens Hospital of Zhengzhou City，Zhengzhou 450000，China;2. Department of Quality Control，Childrens Hospital of Zhengzhou City，Zhengzhou 450000，China 　　[Abstract] Objective To observe the clinical efficacy and the effection on blood lipid level of subclinical hypothyroidism，clinical hypothyroidism treated with levothyroxin. Methods Collected 144 cases hypothyroidism patients，they were randomly divided into two groups according to the order of treatment， 72 cases in each group.Patients in two groups were both given hypoglycemic，pressure control， expansion of coronary artery and other conventional symptomatic treatment， patients in the observation group were given levothyroxine sodium. The hormone levels and blood lipid levels before and after treatment with the two groups were compared. Results After treatment， FT3， FT4and TSH levels of the observation group were （6.77±0.72）pmol/L，（13.56±1.52）pmol/L and （3.25±1.20） mIU/L， significantly improved than before treatment and control group;while TC and TG levels were （4.15±0.88）mmol/L and （1.65±0.32）mmol/L， significantly reduced than before treatment and control group，and the difference between the two groups were statistically significant（P0.05）. Conclusion Levothyroxine treatme