臍血铅与初乳铅含量与新生儿神经行为发育关系20118.docVIP

脐血铅与初乳铅含量与新生儿神经行为发育关系 刘康生12 郝加虎1 顾平清2 桂凌 2 时娟3 戴春芳4徐飞5 1、安微医科大学公共卫生学院儿少妇幼系 2、南京妇幼保健院检验科3、南京妇幼保健院儿保科4南京妇幼保健院产科5、南京儿童医院检验科 [摘要] 目的　探讨在宫内低水平铅暴露状态下,新生儿脐血铅含量及初乳铅铅含量与神经行为发育的关系。方法　随机选取南京市妇幼保健院医院产科2010-01/04出生的足月新生儿170例。以脐血铅和初乳铅铅含量作为新生儿铅暴露的指标,新生儿神经行为（NBNA）发育评分作为效应指标。结果 高暴露组在新生儿主动肌张力、原始反射,和神经行为发育总评分上低于低暴露组，差异有统计学意义(t=4.625，p0.05),在新生儿行为能力、被动肌张力、一般估价上差异无统计学意义。 结论 初乳铅脐血铅水平和与婴儿的早期发育有关,铅可通过乳汁和脐血造成新生儿的铅接触,对新生儿婴儿早期神经行为发育产生不良影响。 [关键词] 新生儿; 脐血铅; 乳铅; 神经行为发育; 早期指标. Relationship Between Lead Levels in Umbilical Cord Blood /Foremilk and Neonatal Neurobehavioral Development LIU Kang-sheng, HAO Jia-hu, GU Ping-qing, et al. School of Public Health, Anhui Medical University, Hefei 230032, Anhui Province, China. Department of Laboratory. Nanjing Maternity and Child Health Care Hospital Nanjing, 210004, Jiangsu Province, China. Abstract Objective To explore the relationship between lead levels in umbilical cord blood and foremilk and the neurobehavioral development of neonates with intrauterine exposure to lead at low level. Methods Totally 170 neonates born in Nanjing Maternity and Child Health Care Hospital were randomly selected to evaluate their neurobehavioral development according to the indicators of lead levels in umbilical cord blood and foremilk. Results The scores of initiative muscle tension, primitive reflex and neonatal neurobehavioral development in high exposure group were lower than those in low exposure group, the differences were statistical significant (t=4.625，p0.05). The differences on neonatal behavior and passive muscle tension had no statistical significance. Conclusion The lead levels in umbilical cord blood and foremilk were related with the early development of neonates. Neonates could be exposed to lead through umbilical cord blood and foremilk, which is harmful to the neurobehavioral development of neonates or infants. Key words neonate; lead in umbilical cord blood; foremilk; neurobehavioral development; indicator 随着我国工业化和城市化进程的加快,环境铅污染问题逐渐突出,并成为影响