(西北工业大学课程设计初模版.docVIP

本科课程设计论文 基于3D引擎的生物基因的三维重构技术 专业名称：自动化 学生姓名：许庆丰 指导教师：杨宁 课程 任务书 题目 基于3D引擎的生物基因的三维重构技术 指导思想和目的要求 熟悉3D引擎、生物基因的基本原理；对基于3D引擎的3D重构方法进行综述；阅读最新国内外参考文献8篇以上。 两周完成设计任务，提交5000字以上的小论文。附参考文献并在论文上相应位置进行标注 主要技术指标 1.3D引擎技术 2.ChIA-PET技术 3.遗传算法原理 学生 ___________ 指导教师 ___________ 系主任 ___________ 摘要 关键词 Abstract By looking up information literature, understand the basic meaning and content of 3 d engine technology, understand the structure and principle of the biological gene. Learned by ChIA PET technology can detect gene interactions and structure.Understanding the principle of genetic algorithm and the basic application Chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) is a whole-genome approach for long-distance chromatin interaction analysis. It is a technique that incorporates chromatin immunoprecipitation, chromatin prox-imity ligation, paired-end tag, and next-generation sequencing to study gene expression and regulation in the genome’s three-dimensional folding and looping state. ChIA-PET has been applied to the identification of the estrogen-receptor-a-binding sitesand the interactions among the binding sites in human breast adenocarcinoma cells. With more protein factors being found andtheir antibodies being used, it will allow real-time and whole-genome identification of the DNA replication and transcription-involved protein factor-binding sites and the interactions among the binding sites, which has a great significance to reveal themechanisms of gene regulation and the pathogenesis of diseases. Key words：hromosomes；genes；three-dimensional structure；ChIA-PET 目 录 第一章 基本概念介绍.............................................................................................6 1.1 3D引擎简介 ....................................................................................................6 1.2 生物基因简介...........................................