ppt课件-p h a s e i i d r u g m e t a b o l i s m glucuronidation(p h s e我d r u g m e t b o l i s m glucuronidation).pptVIP

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ppt课件-p h a s e i i d r u g m e t a b o l i s m glucuronidation(p h s e我d r u g m e t b o l i s m glucuronidation).ppt

* * * Specific inducers: Some specific inducers have been reported, usually based upon measures based upon a particular substrate, eg. clofibric acid induces somewhat specifically the conjugation of bilirubin. However, studies of what specific isozyme is induced are often not provided as the human or rat isozymes are not all presently known, nor are the substrates for known isozymes necessarily well documented. Therefore, it is difficult to predict the effects of “specific” inducers. Drug Metab. Dispos. 26: 91 – 97 (1998). Chemico-Biological Inter. 103: 167 – 178 (1997). * The Gunn rat a

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