时间药理学与临床合理用药幻灯片.pptVIP

时间药理学与临床合理用药 CHRONOPHARMACOLOGY AND RATIONAL MEDICATION 时间药理学Chronopharmacology 研究药物的体内过程和药物效应与机体生物周期的相互关系 生物周期性(bioperiodicity) 机体的功能状态随时间推移所呈现的规律性变化，包括近日节律 (昼夜节律circadian rhythm)和近年节律(circannual rhythm) The distinguish on the effect of drug while using in different time The same disease, same medicine, same dose, take in different time of a day, there are different effect and toxicity. The degree of the difference may be twofold, or even decades times. The revolving circling movement of time which can be compared to the circadian rhythms that regulate