Research on the Influence of HPMC Release the Bupropion Hydrochloride Sustained Release Tablets.docVIP

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2017-01-23 发布于北京
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Research on the Influence of HPMC Release the Bupropion Hydrochloride Sustained Release Tablets.doc

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Research on the Influence of HPMC Release the Bupropion Hydrochloride Sustained Release Tablets 　　Abstract: Objective Study of bupropion hydrochloride gel matrix sustained release tablet and the preparation method, test the skeleton material of hydroxypropyl methyl cellulose influencing drug release for evaluation, explore the preparation of sustained release tablets of optimization method. Method With hydroxypropyl methyl cellulose as skeleton material, according to the different prescription preparation of bupropion hydrochloride sustained release tablets. Different HPMC viscosity, Consumption, particle size, compression pressure and slurry rotational speed and other factors, analysis the influence on drug release rate.Through the release of test evaluation of sustained release effect, and the preliminary study on the drug release characteristic. With hydroxypropyl methyl cellulose ( HPMC ) as skeleton material, with citric acid citrate as a porogenic agent, direct powder tabletting method of bupropion hydrochloride sustained release tablets; by using single factor and orthogonal experiment method to investigate HPMC different viscosity, different Consumption, different particle size, different compression pressure, different pulp rotational speed and other factors on the release of delivery rate. Result Select HPMC-K100M for bupropion hydrochloride sustained release tablets of the skeleton materials; reinforcing materials of high viscosity HPMC K100M and main drug quality ratio of 1: 1; HPMC particle diameter of 125μm, make use of these conditions to preparation of bupropion hydrochloride sustained release tablets for optimal prescription conditions. Conclusion bupropion hydrochloride sustained release tablets on the drug release rate is mainly affected by HPMC viscosity and dosage effect. Along with the tablet of HPMC viscosity increased, the drug is released slowly. HPMC viscosity, dosage on the drug release rate has significant influence. 　　Key words: Ph