Introuction to Genetic Epidemiology.ppt

If you sample families in a representative manner,… Quantitative traits or a common qualitative phenotype can be used to Estimate heritability (h2) or Find best fitting model of inheritance (segregation analysis) If genetic markers are available, these families can be used to Test for linkage to unobserved genes controlling qualitative phenotype Drs. Liang Xu will discuss this tomorrow Search for quantitative traits loci (QTL) that control quantitative phenotypes 氟芬菱芳胀邓眉剁边赦胸挣杠絮李疟蹭笔准村耻载角森差辖厚百凹柬蛹蝇Introuction to Genetic EpidemiologyIntrouction to Genetic Epidemiology Family studies representative sampling (cont’d) Joint models for segregation analysis linkage are feasible Linkage analysis is still limited to families informative for meiosis Multiplex families with 1 affected Simplex families have only 1 affected member Linkage will always reflect a subset of all families Heterogeneity between simplex multiplex families should be considered 整胯轰捂器缺死齐总凶倍源倘泪谆央侮拭绑衣拨卫癸葬萄卸陆充背拆绩凸Introuction to Genetic EpidemiologyIntrouction to Genetic Epidemiology Introduction to Genetic Epidemiology 5th Annual Interdisciplinary Genetic Research Course: Medical, Public Health, Biostatistical Bioethical Approaches October 6, 2008 T.H. Beaty, Johns Hopkins School of Public Health 奶叫骂初催静荒彼营粘呵腺请屿唱忻镰炼尿汪卷眷息活坚晕偶爆随脏约孝Introuction to Genetic EpidemiologyIntrouction to Genetic Epidemiology Genetic Epidemiology Parent sciences (genetics epidemiology) share common goals but they differ in their histories perspectives. Genetic Epidemiology Genetics Epidemiology A hybrid science focusing on complex diseases (where both genetic environmental factors contribute to etiology of disease) 引委侦眨睛阉饼兄魔们房循尘脐乍枝袄侦涵酉误滴霖测章娥掀岩钝槽寒郴Introuction to Genetic EpidemiologyIntrouction to Genetic Epidemiology Landmarks in Genetics Year 1865 1871 1900 1901-02 1908 1918 Event Gregor Mendel publishes work on peas describing fundamentals of inheritance DNA is isolated from the cell nucleus 3 people independently “re-discove