ppt课件-b2- fri-4-2- rowbottom（b2 - fri-4-2 rowbottom）.pptVIP

Going beyond anatomical adaptive radiotherapy Going beyond anatomical adaptive radiotherapy Going beyond anatomical adaptive radiotherapy – the Steinbeck study? Study of 32 mice with human prostate xenografts. Receiving androgen deprivation therapy and/or radiotherapy Repeat DW-MRI and DCE-MRI give apparent diffusion coefficient (ADC) and vascular biomarker (Ktrans) Treatment response measured 30 days posts RT (tumour volume) Going beyond anatomical adaptive radiotherapy – the Steinbeck study Going beyond anatomical adaptive radiotherapy – the Steinbeck study Going beyond anatomical adaptive radiotherapy – the Steinbeck study(from mice to men) High-risk prostate cancer patients...... If we can predict tumour response from MR imaging (DW DCE-MRI)...... Can we predict normal tissue response? Can we stratify prostate cancer patients? Can we modify treatment after 2 weeks of radiotherapy? Escalation/de-escalation? Normal tissue dose modification? Pilot study (20 patients) to begin in 2014 “Data is not information, information is not knowledge, knowledge is not understanding, understanding is not wisdom” Clifford Stoll Manchester famous for 3 things – Rain – Football – Discovery of PROTONS! Picture Luke Fildes – The Doctor 1887 Personalised medicine – Target the treatment to the patient characteristics – creates sub-populations rather than giving the medicine that benefits the most people on average. Currently treat patients according to population base, e.g. all prostate patients get the same dose/fractionation. Personalised radiotherapy – use additional information (genomics etc) to sub-divide patients with the same disease and individualise the radiotherapy. IGRT allows us to monitor the patient during treatment and adapt if necessary. Movie1_tumourregression * Movie2_weightloss * Movie3_dailybladder * Movie4_mediastinalchanges * HN_Replan_dynamicplanningexample * * Lung_Replan_dynamicplanningexample * What is the consequence of IGRT based Radiotherapy?