疾病的分子基础__培训课件.pptVIP

* 一些重要的TSG TSG 染色体定位 TSG 染色体定位 p53 17p13.1 RB 13q14.1 WT1 11p13 p16 9q21 P15 9q21 NF1 17q1.2 P21 6p21.1 p27 12p13 BRCA1 17q12 DCC 8q21.2 FAP 5q21 p73 1p36.33 NM23 17q21.3 * 癌基因 Normal genes (regulate cell growth) 1st mutation (leads to accelerated cell division) 1 mutation sufficient for role in cancer development 抑癌基因 Normal genes (prevent cancer) 1st mutation (susceptible carrier) 2nd mutation or loss (leads to cancer) Epig